116 articles - From Friday Mar 14 2025 to Friday Mar 21 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Endoscopy |
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Endoscopic Sustainability PrimAry Reporting Essentials (E-SPARE): European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. However, there are currently no guidelines or frameworks which provide specifically for the reporting of endoscopy sustainability studies, and a variety of metrics and assessment tools have been employed in the literature. To improve the clarity, transparency, and quality of reporting, the European Society of Gastrointestinal Endoscopy (ESGE) has developed a reporting framework for the community of researchers interested in conducting studies on sustainable GI endoscopy. |
Management of epithelial precancerous conditions and early neoplasia of the stomach (MAPS III): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG) and European Society of Pathology (ESP) Guideline update 2025. pylori eradication for patients with precancerous conditions and after endoscopic or surgical therapy. ESGE/EHMSG/ESP recommend that patients should be advised to stop smoking and low-dose daily aspirin use may be considered for the prevention of gastric cancer in selected individuals with high risk for cardiovascular events. |
Validation of the GPAT - the Global Polypectomy Assessment Tool: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. CONCLUSIONS : GPAT allows standardized scoring of polypectomies, with moderate IOA among gastroenterologists and correlation with subjective impressions of polypectomy quality. GPAT could standardize assessment of trainee polypectomy competency offering structured feedback on performance. |
| J Hepatol |
EASL-ERN Clinical Practice Guidelines on Wilson's disease. Acute liver failure is challenging as making a diagnosis is difficult and pharmacological therapy may not be sufficient to save life. Liver transplantation has a well-defined role in Wilsonian acute hepatic failure but may also be considered in neurological disease. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
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Meta-Analysis: Pregnancies With Inflammatory Bowel Disease Complicated by Intrahepatic Cholestasis of Pregnancy. Thiopurine exposure in patients with IBD is associated with an increased risk of ICP. Clinicians should monitor pregnant patients with IBD exposed to thiopurines for symptoms of ICP. |
| Am J Gastroenterol |
Social Determinants of Health Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease Prevalence and Severity: A Systematic Review and Meta-analysis. Diet quality was the most consistent SDOH associated with disease prevalence and severity in MASLD, with other SDOH showing inconsistent associations. Prospective assessments using consensus, validated tools to assess the impact of specific SDOH on MASLD burden in heterogenous patient populations are needed to inform public health interventions. |
| Clin Gastroenterol Hepatol |
Proton Pump Inhibitors for Inducing and Maintaining Remission in Eosinophilic Esophagitis: An Updated Systematic Review and Meta-Analysis. PPI therapy induces clinic-histological remission in almost half of pediatric and adult EoE patients. Response to PPIs is significantly higher in Japan. Sustained remission is common on tapering PPI doses. |
| Endosc Int Open |
Conventional small-bowel capsule endoscopy reading vs proprietary artificial intelligence auxiliary systems: Systematic review and meta-analysis. AI-assisted SBCE reading outperforms conventional human review in terms of detection accuracy and sensitivity, remarkably reducing reading times. AI in this setting could be a game-changer in reducing endoscopy service workload and supporting novice reader training. |
Peroral endoscopic myotomy with fundoplication (POEM-F) for achalasia: Systematic review and meta-analysis. It appears to offer clinical benefit in mitigating post-POEM GER. However, further standardization for evaluating clinically significant post-POEM GER and long-term benefit of POEM-F is warranted. |
| Endoscopy |
Cold snare polypectomy versus hot endoscopic mucosal resection for large non-pedunculated colorectal polyps: a systematic review and meta-analysis of randomized controlled trials. CSP has nearly double the recurrence risk of H-EMR for LNPCPs. However, its superior safety profile may make it a preferable option for patients where procedural safety is prioritized over radicality, such as those with extensive comorbidities. |
| Gastrointest Endosc |
Endoscopists' knowledge, perceptions and attitudes toward the use of artificial intelligence in endoscopy: A systematic review. There is a positive attitude toward the use of AI in endoscopy. Concerns regarding the impact on clinical practice, costs and medicolegal considerations remain. Establishing robust regulatory frameworks is crucial to the integration of AI into endoscopy. |
| Hepatology |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Association Between Viral Replication Activity and Postoperative Recurrence of HBV-Related Hepatocellular Carcinoma. The association between HBV replication activity and the risk of HCC recurrence varied depending on cirrhosis, providing important insights for optimising the timing of AVT and post-operative surveillance strategies. |
Risk Factors for Liver Disease Cluster Geographically: A Precision Public Health Analysis of a UK City. Liver blood tests were more frequently done in areas of low-disease prevalence. These results illustrate health inequalities and support public health policies to reduce incident liver disease. |
| Am J Gastroenterol |
Diagnosis of Acute on Chronic Liver Failure in critically ill patients with cirrhosis using administrative data. Adding laboratory thresholds increased PPVs. ICD-10 codes accurately identify organ failures in critically ill patients with cirrhosis and may be helpful for identifying cases of ACLF within administrative data. |
International, multicenter analysis of endoscopic full-thickness resection of duodenal neuroendocrine tumors. EFTR of dNET showed high technical success and R0 resection rates and very low rate of severe AEs. It could become endoscopic treatment of choice for dNET, at least for lesions not within proximity of the pylorus. |
Microscopic colitis and risk of venous thromboembolism: A nationwide matched cohort study. In this population-based study, individuals with MC had a 21% higher risk of VTE compared with reference individuals, equivalent to one extra VTE event for every 37 MC individuals followed for ten years. |
Minimum platelet count threshold for safe colonoscopic polypectomy: A large-scale propensity scored-matched analysis. Patients with platelet counts < 90,000/μL exhibited significantly elevated rates of IPPB and DPPB, suggesting that maintaining platelet levels above this threshold may be crucial for ensuring the safety of colonic polypectomy. |
Mirikizumab Improves Quality of Life and Work Productivity in Patients with Moderately to Severely Active Crohn's Disease: Results from the Phase 3 VIVID-1 study. Patients with moderately to severely active CD treated with mirikizumab reported clinically meaningful improvements in HRQoL and work productivity versus placebo at Week 12 which were maintained at Week 52. |
Symptom Resolution and Meaningful Improvement in Quality of Life With Risankizumab in Patients With Ulcerative Colitis: Post Hoc Analysis of the Randomized INSPIRE and COMMAND Studies. RZB treatment improved UC-related symptoms and HRQoL outcomes compared with PBO in patients with UC. NCT03398148; NCT03398135. |
| Clin Gastroenterol Hepatol |
Biomarkers of histological response in lanifibranor-treated patients with metabolic dysfunction-associated steatohepatitis. Results from this analysis show evidence that baseline values and changes in selected serum biomarkers can aid in predicting histological response in MASH under lanifibranor treatment. These findings support utilizing a similar approach in a larger sample size (NATiV3, NCT03008070). |
CHOLECYSTECTOMY IS A RISK FACTOR FOR MICROSCOPIC COLITIS: A NATIONWIDE POPULATION-BASED MATCHED CASE CONTROL STUDY. Cholecystectomy is associated with an increased risk of subsequent MC. These findings have implications for surgeons and general practitioners and underscore the need for further research into the underlying association between bile-acid and microscopic colitis. |
Early occurrence of hepatic encephalopathy following TIPS-insertion is linked to impaired survival: a multicenter cohort study. Early HE post-TIPS is associated with significantly reduced survival. Therefore, patients who experience early HE or have a history of HE should be closely monitored by physicians, as they constitute a particularly vulnerable group with impaired survival. |
High Rates of Dysplasia in a Population-Based Analysis of "Incidental" Barrett's Esophagus. BE is found incidentally at rates approaching those seen in dedicated screening exams. Incidental BE is not only common but has similar or worse high-risk features as BE in traditional screening and surveillance populations, given segment length and dysplasia yield. Refinement of BE screening programs could yield cases of similar risk of progression as traditional programs. |
Intestinal Ultrasound Findings and Their Prognostic Value in Early Crohn's Disease - a Copenhagen IBD Cohort Study. Transmural remission is an achievable outcome target for many newly diagnosed Crohn's disease patients and is associated with a favorable clinical outcome, including sustained steroid-free clinical remission. Further, intestinal ultrasound findings at diagnosis predict future ileocecal resection. |
Risk of age-related and disease-related complications and mortality in elderly-onset IBD - a population-based study. Compared with non-IBD elderly, EO-IBD have similar risk for death and complications. Compared to AO-IBD, EO-IBD are at higher risk for abdominal surgery, but not for perianal surgery. |
| Endosc Int Open |
Comparison of traction vs. snare as rescue methods for challenging colorectal endoscopic submucosal dissection: Propensity score-matched study. Utilizing a traction device as a rescue technique in difficult colorectal ESD resulted in higher en bloc and R0 resection rates compared with conversion to snare resection. Initiating traction within 75 minutes may contribute to reducing overall procedure time for challenging colorectal ESD cases. |
Cost-effectiveness analysis of artificial intelligence-aided colonoscopy for adenoma detection and characterization in Spain. Sensitivity analyses confirmed model robustness. The results of this analysis suggest that CADe/CADx would result in a dominant strategy versus standard practice in patients undergoing colonoscopy in Spain. |
Efficacy of a higher-flexibility duodenal stent for palliation of gastric outlet obstruction. AE rates were 18% vs 28%, respectively. The WallFlex Duodenal Soft stent effectively treats GOOS in palliative patients and seems to be associated with longer symptom-free survival and lower AE rates compared with previous duodenal SEMS designs. |
Endoscopic band ligation alone and combined with clipping for colonic diverticular bleeding: Retrospective comparative study. Using EBL-C for CDB may be more effective in preventing rebleeding than using EBL alone because it facilitates better ligation of the target diverticulum. Treatment of diverticula that are hard and difficult to manage with suction remains a challenge. |
Endoscopic submucosal dissection for proximal colonic lesions: An effective therapeutic option. Median follow-up was 36 months; three of 97 recurrences (3.1%) at 6 months and one of 85 recurrence (1.2%) at 36 months were reported, which were al endoscopically treated. In expert hands, ESD is effective and safe for proximal colonic lesions at risk of SMIC for the favorable balance between risk of AEs and benefit of avoiding unnecessary surgery, even for early CRC. |
Endoscopic ultrasound gastroenterostomy vs duodenal stenting for malignant gastric outlet obstruction: Cost-effectiveness study. Using a tornado diagram, the model was most sensitive to the probability of mortality in patients with duodenal stents compared with EUS-GE. In patients with malignant GOO, EUS-GE is a cost-effective palliative intervention compared with duodenal stenting. |
Enhancing diagnostics: ChatGPT-4 performance in ulcerative colitis endoscopic assessment. ChatGPT-4 has the potential to assess mucosal inflammation severity from endoscopic images of UC patients, without prior configuration or fine-tuning. Performance rates were comparable to those of IBD specialists. |
Impact of a training intervention on upper gastrointestinal endoscopy quality over time: Multicenter comparative cohort study. Male patients (3.2%, 95% CI 0.7-5.7), alarming features (-3.1%, 95% CI -5.6 to -0.5), and endoscopist age (-0.4% increment per year, 95% CI -0.8 to -0.1) were associated with higher quality scores. Adherence to the ESGE and BSG procedure performance measures for UGI endoscopy persistently increased after a 1-hour face-to-face training intervention, suggesting that a simple training intervention tool can improve the quality of UGI endoscopy and potentially could prevent missed lesions. |
Impact of virtual reality distraction during colonoscopy vs intravenous deep sedation: Results of a single-center randomized controlled trial. This RCT provides preliminary data to better understand the feasibility of VRD for colonoscopy. We have not identified differences in procedure outcomes compared with conventional IVS, but nevertheless, higher pain and lower comfort scores were reported. |
Implementing educational interventions and key performance measures sustains quality of endoscopic assessment in patients with Barrett's esophagus. Sustaining improvements in quality metrics in Barrett's endoscopy is important. Our study suggests that regular, replicable education interventions have a positive effect and allow sustained long-term improvements in quality metrics. |
Novel water-based automated endoscope cleaning process vs conventional manual cleaning for reducing duodenoscope contamination. These results are promising. However, future studies should confirm these findings in larger samples and explore other advantages of using the AT in duodenoscope cleaning. |
Orally peppermint oil in small bowel capsule endoscopy: Novel approach to improve completion rates in patients at risk of delayed gastric transit. Diagnostic yield and bowel preparation quality were consistent across al groups. Oral peppermint oil solution is a safe and effective alternative to traditional prokinetics, enhancing SBCE completion rates while reducing time and resource use in the endoscopy unit. |
Prevalence and endoscopic-histological correlation of premalignant gastric lesions at a university hospital in Uruguay. The endoscopic-histological correlation of both CAG and IM was low, raising the need for biopsy for diagnosis in al cases, regardless of HD-WLE findings. Although prevalence of gastric pre-neoplastic conditions in this group of Uruguayan patients was comparable to those described in countries with a high incidence of GC, a low proportion of high-risk stages (III and IV) was identified. |
Thermal changes in guidewires used during endoscopic retrograde cholangiopancreatography during electrical conductance: Ex-vivo safety experiment. Also, the Glidewire 0.018" and the Visiglide 0.025" produced visible sparks along their distal ends with defects in insulation found later under microscopic evaluation. In our ex-vivo study, minimal heat was generated via electrical conductivity despite direct current, suggesting negligible risk of thermal injury during sphincterotomy. |
| Endoscopy |
Recurrences after piecemeal endoscopic mucosal resection of 10-20mm non-pedunculated colorectal polyps: a multicenter cohort study. ESC scar identification was moderate but improved with tattoo placement. Although early surveillance could be considered to avoid missing recurrences, the small recurrence size and absence of high-grade dysplasia suggest that modestly extending the interval beyond that of our study may still allow timely detection of recurrences and metachronous lesions. |
| Gastroenterology |
Capsule endoscopy-guided proactive treat-to-target versus continued standard care in patients with quiescent Crohn's disease: A randomized controlled trial. Of 221 VCE ingested, there was a single (0.4%) temporarily-retained spontaneously resolved event. VCE-guided treat-to-target strategy for patients with CD in remission confers superior clinical outcomes compared with continued standard-care. |
Efficacy and Safety of Guselkumab Subcutaneous Induction and Maintenance in Participants with Moderately to Severely Active Crohn's Disease: Results from the Phase 3 GRAVITI Study. Subcutaneous guselkumab for both induction and maintenance was efficacious in treating participants with moderately to severely active CD. Safety findings were consistent with those of guselkumab in approved indications, including ulcerative colitis. |
From "Burnt-Out" to "Burning-Out": Capturing Liver Fat Loss in Patients with Advanced Metabolic Dysfunction-Associated Steatotic Liver Disease from A Dynamic Perspective. The "burning-out" group had higher cumulative incidences of adverse outcomes than patients with consistently high CAP and moderate/low LSM values (P <0.0001). Continuous hepatic fat loss accompanied by fibrosis progression, referred to as "burning-out", was observed in advanced MASLD and associated with high rates of all-cause mortality, LREs and hepatic decompensation. |
Mucosal macrophages govern intestinal regeneration in response to injury. This study identifies macrophages as essential contributors to intestinal regeneration beyond their innate immune response. Targeting macrophages therapeutically may hold promise in enhancing regeneration and improving the quality of life for cancer survivors. |
The efficacy of texture and color enhancement imaging (TXI) observation in the detection of colorectal lesions: a multicenter, randomized controlled trial (deTXIon study). This study did not demonstrate the superiority of TXI over WLI in detecting neoplastic lesions. However, TXI may be effective in detecting flat polyps. |
| Gut |
Diagnostic efficacy of an extracellular vesicle-derived lncRNA-based liquid biopsy signature for the early detection of early-onset gastric cancer. The low levels of this biomarker in postsurgery and other gastrointestinal tumour plasma samples indicated its GC specificity. The newly developed EV-lncRNA signature effectively identified EOGC patients at a resectable stage with enhanced precision, thereby improving the prognosis of patients who would have otherwise missed the curative treatment window. |
| Hepatology |
Deep learning analysis of magnetic resonance imaging accurately detects early-stage perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis. The 3D DenseNet-121 MRI model effectively detects early-stage pCCA in PSC patients. Compared to expert radiologists, the model missed fewer cases of cancer. |
HLA-DQB1*03:01 and risk of Hepatitis B virus-related hepatocellular carcinoma. HLA-DQB1*03 01 and its three key amino acids are associated with an increased HBV-related HCC risk. This association may be explained by the low binding affinity to HBV antigen, resulting in poor control of viral load and increased inflammation, as evidenced by sPD-1 levels. |
Higher level of Hepatitis B Surface antigen associated with delayed development of hepatocellular carcinoma in immune-tolerant patients. Predictive roles of HBV DNA and HBsAg levels in HCC development differ between HBeAg-negative and HBeAg-positive patients. Particularly, among immune-tolerant patients, HBsAg levels ≥10,000 IU/mL showed delayed development of HCC, suggesting HBsAg as a biomarker to define genuine immune-tolerant patients. |
Population perspectives on benefits and harms of screening for metabolic dysfunction-associated steatotic liver disease. This population-based survey demonstrates that the perceived benefits of proactive MASLD screening, such as increased awareness, lifestyle changes, and early diagnosis, outweigh the harms. These findings highlight the importance of early screening through patient-centered protocols to improve health outcomes. |
Pre-B-Cell leukemia transcription factor 1 contributes to liver fibrosis by enabling IL-7 signaling in hepatic stellate cells. Our data uncover a previously unappreciated role for PBX1 in HSC activation and provide proof-of-concept for targeting IL-7 signaling in the intervention of liver fibrosis. |
| J Hepatol |
Norway rat hepacivirus resembles hepatitis C virus in terms of intra-host evolution and escape from neutralizing antibodies. This study demonstrates the correlation between nAbs and viral evolution during long-term NrHV infection. The observed humoral immunity for NrHV infection closely resembles that of chronic HCV infection, where late-emerging high-level nAbs fail to clear evolving viral populations, thereby contributing to the evasion of the adaptive immune response. Preexisting antibodies do, however, protect from infection. |
Simultaneous liver transplant and sleeve gastrectomy provides durable weight loss, improves metabolic syndrome and reduces allograft steatosis. LTSG results in sustained weight loss, resolution of diabetes and hypertension, and reduced recurrence of steatosis and possibly fibrosis compared to LT alone. It confers no increase in mortality or graft loss. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
A comprehensive review of geriatric syndromes and assessment in older adults with inflammatory bowel diseases. Geriatric syndromes are prevalent and negatively impact older patients with IBD. Systematic assessment for their presence and multidisciplinary interventions to improve them are important to improve outcomes of older adults with IBD. |
Epidemiology, Natural History and Treatment of IBD in Africa: A Scoping Review. We identified a paucity of publications regarding the risk factors, burden, and outcomes of IBD in Africa. There were few prospective studies and regional variations in representation. There is a need for more prospective data to inform our knowledge and management strategies accurately. |
| Endosc Int Open |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
| Gut |
| J Hepatol |